BDBM50012917 CHEMBL3261327::USRE46024, 15

SMILES CC(C)c1cc(Cc2c(Br)cc(CC(O)=O)cc2Br)n[nH]c1=O

InChI Key InChIKey=GPQLQJCVSFKHSX-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50012917   

LigandPNGBDBM50012917(CHEMBL3261327 | USRE46024, 15)
Affinity DataEC50:  601nMpH: 7.0Assay Description:Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetThyroid hormone receptor beta(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012917(CHEMBL3261327 | USRE46024, 15)
Affinity DataEC50:  600nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012917(CHEMBL3261327 | USRE46024, 15)
Affinity DataEC50:  750nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed