BDBM50012913 CHEMBL3261333::USRE46024, 16

SMILES CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)nn(C)c1=O

InChI Key InChIKey=JFIWDBBXUIEFQL-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50012913   

LigandPNGBDBM50012913(CHEMBL3261333 | USRE46024, 16)
Affinity DataEC50:  66nMpH: 7.0Assay Description:Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

TargetThyroid hormone receptor beta(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012913(CHEMBL3261333 | USRE46024, 16)
Affinity DataEC50:  40nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012913(CHEMBL3261333 | USRE46024, 16)
Affinity DataEC50:  330nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed