BDBM50012903 CHEMBL3261328::USRE46024, 17

SMILES CC(C)c1cc(Sc2c(Cl)cc(CC(O)=O)cc2Cl)n[nH]c1=O

InChI Key InChIKey=URNDNHCCRPRCLG-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50012903   

LigandPNGBDBM50012903(CHEMBL3261328 | USRE46024, 17)
Affinity DataEC50:  2.04E+3nMpH: 7.0Assay Description:Thirty microliters of H6-TRβ (50 nM) in 50 mM Hepes, pH 7.0, 1 mM DTT, 0.05% NP40 and 0.2 mg/ml BSA (Binding Buffer) was mixed with an equal vol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

TargetThyroid hormone receptor alpha(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012903(CHEMBL3261328 | USRE46024, 17)
Affinity DataEC50:  8.88E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012903(CHEMBL3261328 | USRE46024, 17)
Affinity DataEC50:  2.04E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed