BDBM50009864 CHEMBL274833::[2-Methyl-1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-naphthalen-1-yl-methanone

SMILES Cc1c(C(=O)c2cccc3ccccc23)c2ccccc2n1CCN1CCOCC1

InChI Key InChIKey=MCYSYVGXDRTALC-UHFFFAOYSA-N

Data  5 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50009864   

TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataIC50: 19nMAssay Description:Concentration of compound required to inhibit 50% of [3H]WIN-55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenylate cyclase type 5(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataEC50:  370nMAssay Description:Compound was evaluated for inhibition of hormone stimulated Adenylate cyclase activity in N18TG2 membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataIC50: 73nMAssay Description:Binding affinity against brain Cannabinoid receptor 1 using [3H]CP-55940 as radioligand at 1.1 nM concentrationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin-H2 D-isomerase(Mouse)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataIC50: 15nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in mouse vas deferensMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataKi:  14nMAssay Description:Evaluated for binding affinity against recombinant human peripheral cannabinoid receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetCannabinoid receptor 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataKi:  638nMAssay Description:Evaluated for binding affinity against recombinant human central cannabinoid receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataKi:  3.55E+7nMAssay Description:Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataKi:  6.61E+7nMAssay Description:Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]WIN-55212-2 in rat forebrain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009864(CHEMBL274833 | [2-Methyl-1-(2-morpholin-4-yl-ethyl...)
Affinity DataKi:  6.61E+7nMAssay Description:Binding affinity at cannabinoid receptor 1 using rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed