BDBM50009361 CHEMBL3233837::US9346814, Cmpd No 25 Example 30

SMILES O=C(CNC(=O)c1ccnc2cc(Nc3ccccc3)ccc12)N1CCC[C@H]1C#N

InChI Key InChIKey=JYZCEZUNDURZDS-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50009361   

TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 59nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 9(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 2.08E+4nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 2(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 2.03E+3nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 2(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009361(CHEMBL3233837 | US9346814, Cmpd No 25 Example 30)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed