BDBM50009332 CHEMBL3233836::US9346814, Cmpd No 26 Example 31

SMILES O=C(CNC(=O)c1ccnc2cc(ccc12)-c1ccccc1)N1CCC[C@H]1C#N

InChI Key InChIKey=YUCQGCQXOAXMDQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50009332   

TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 64nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 4(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 9(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 5.00E+4nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetDipeptidyl peptidase 2(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 1.00E+5nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 8.70E+3nMpH: 8.3 T: 2°CAssay Description:Enzyme activities were determined kinetically in a final volume of 200 μl for 10 minutes at 37° C. by measuring the initial velocities of pNA ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetProlyl endopeptidase(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProlyl endopeptidase FAP(Mouse)
Universiteit Antwerp

US Patent
LigandPNGBDBM50009332(CHEMBL3233836 | US9346814, Cmpd No 26 Example 31)
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed