BDBM50008854 2-Benzo[b]thiophen-4-yl-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide; hydrochloride::CHEMBL543331

SMILES CN([C@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1cccc2sccc12

InChI Key InChIKey=SYHJZCCNQDFHJQ-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50008854   

TargetKappa-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  3.70nMAssay Description:Opioid receptor kappa affinity, determined with [3H]etorphine in the presence of excess unlabeled [D-Ala2-MePhe4-Glyol5]-enkephalinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity against Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity towards Opioid receptor kappa 1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity for the Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  9.60nMAssay Description:Binding affinity for the Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  410nMAssay Description:Compound was evaluated for the Opioid receptor mu affinity determined with [3H][D-Ala2-MePhe4-Gly-ol5]-enkephalin (DAGOL) in the presence of excess u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  410nMAssay Description:Binding affinity towards opioid receptor mu was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  880nMAssay Description:Binding affinity for the Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity for the Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity for the Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Parke-Davis Research Unit

Curated by ChEMBL
LigandPNGBDBM50008854(CHEMBL543331 | 2-Benzo[b]thiophen-4-yl-N-methyl-N-...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity for the Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed