BDBM50008848 (+)2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide::(RS)-2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide(U 50488)::2-(3,4-Dichloro-phenyl)-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide::CHEMBL301867

SMILES CN([C@@H]1CCCC[C@@H]1N1CCCC1)C(=O)Cc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=VQLPLYSROCPWFF-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50008848   

TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50008848(CHEMBL301867 | 2-(3,4-Dichloro-phenyl)-N-methyl-N-...)
Affinity DataIC50: 194nMAssay Description:Binding affinity for sigma opioid receptor using [3H](+)-3-PPP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50008848(CHEMBL301867 | 2-(3,4-Dichloro-phenyl)-N-methyl-N-...)
Affinity DataKi:  118nMAssay Description:Compound was evaluated for binding affinity towards sigma opioid receptor using [3H]DTG in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50008848(CHEMBL301867 | 2-(3,4-Dichloro-phenyl)-N-methyl-N-...)
Affinity DataKi:  221nMAssay Description:Compound was evaluated for binding affinity towards sigma opioid receptor using [3H](+)-3-PPP in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Institute of Digestive

Curated by ChEMBL
LigandPNGBDBM50008848(CHEMBL301867 | 2-(3,4-Dichloro-phenyl)-N-methyl-N-...)
Affinity DataKi:  2.72E+3nMAssay Description:Compound was evaluated for binding affinity towards Opioid receptor kappa 1 using [3H]BREM in guinea pig ileumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
National Institute of Digestive

Curated by ChEMBL
LigandPNGBDBM50008848(CHEMBL301867 | 2-(3,4-Dichloro-phenyl)-N-methyl-N-...)
Affinity DataKi:  1.40E+4nMAssay Description:Compound was evaluated for binding affinity towards Dopamine receptor D2 using [3H]SULP in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed