BDBM50007838 8-Cyclohexyl-1,3-dipropyl-3,7-dihydro-purine-2,6-dione::8-Cyclohexyl-1,3-dipropyl-3,9-dihydro-purine-2,6-dione::CHEMBL160369

SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1CCCCC1

InChI Key InChIKey=QXHRGKKEMOXVOR-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50007838   

TargetAdenosine receptor A1(Rat)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against adenosine A1 receptor in rat cortex by the displacement of [3H]cyclohexyladenosine (CHA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of 1 nM [3H]- N6 -(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat fat cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Nova Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  2nMAssay Description:Evaluated for binding affinity against Adenosine A1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  2.5nMAssay Description:Antagonist activity against adenosine A1 receptor in human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  120nMAssay Description:Antagonistic activity against adenosine A2 receptor in rat adipocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  190nMAssay Description:Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Human)
National Institutes of Health

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  190nMAssay Description:Inhibition of 5'-(N-ethylcarbamoyl)adenosine-elicited stimulation of adenylate cyclase in human platelet membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2019
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  210nMAssay Description:Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via Adenosine A2 receptor in rat PC12 membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a/A2b(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50007838(CHEMBL160369 | 8-Cyclohexyl-1,3-dipropyl-3,7-dihyd...)
Affinity DataKi:  320nMAssay Description:Binding affinity against adenosine A2 receptor in rat striatum by the displacement of [3H]N-ethyladenosine-5''-uronamide(NECA).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed