BDBM50007583 CHEBI:62882::CHEMBL562310

SMILES c1cc2cccnc2c(c1)NC(=O)c3ccc(cc3)N4C(=O)[C@H]5[C@@H]6C[C@H]([C@H]5C4=O)C=C6

InChI Key InChIKey=ZGSXEXBYLJIOGF-UHFFFAOYSA-N

Data  12 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50007583   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Mouse)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS-1 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Mouse)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of PAPR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 131nMAssay Description:Inhibition of TNKS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Health & Science University

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50007583(CHEMBL562310 | CHEBI:62882)
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed