BDBM50005480 (-)-combretastatin::(Z)-3'-hydroxy-3,4,4',5-tetramethoxystilbene::(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::(combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::(combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol::2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol::2-methoxy-5-(3,4,5-trimethoxystyryl)phenol::2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol::5-(3,4,5-trimethoxystyryl)-2-methoxyphenol::5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol::CHEMBL67::Combrestatin A-4::Combrestatin A4::Combretastastin A-4::Combretastatin::Combretastatin-A4::Combretastin A-4::Z-Combretastatin A-4::combretastatin A-4, (CSA4)::combretastin A4
SMILES COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O
InChI Key InChIKey=HVXBOLULGPECHP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 107 hits for monomerid = 50005480
Affinity DataIC50: 2.00E+3nMAssay Description:Tubulin polymerization was followed turbidimetrically at 350nm in Beckman model DU-7400 and DU-7500 spectrophotometers equipped with electric tempera...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:IC50 values for inhibition of cell growth using MCF-7 cell line were obtained by measuring the amount of total cell protein with the sulforhodamine B...More data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analys...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Abl1 (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Src (unknown origin) assessed as incorporation of [32P] gamma-ATP in to myelin basic protein after 30 mins by autoradiographic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Antitubulin activity against tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Concentration required to inhibit polymerization of tubulinMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Compound was evaluated for inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerization (ITP)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Concentration needed to inhibit tubulin polymerization by 50%More data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentrationMore data for this Ligand-Target Pair
3D Structure (crystal)TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Shenyang Pharmaceutical University
Curated by ChEMBL
Shenyang Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 900nMAssay Description:Inhibition of bovine brain tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization by turbidimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of tubulin polymerization interacting at the colchicine binding site.More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Concentration required for 50% inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of bovine brain tubulin preincubated for 20 mins by turbidimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration required to inhibit tubulin polymerization at 10 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of bovine brain tubulin assemblyMore data for this Ligand-Target Pair
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization incubated for 60 mins by microplate reader based turbidimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of bovine brain tubulin assembly after 20 mins incubation by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 20 mins by turbidimetric analysisMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization extent after 20 mins by turbidimetricallyMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization after 30 minsMore data for this Ligand-Target Pair
TargetSimilar to alpha-tubulin isoform 1/Tubulin beta-2B chain(Bovine)
Purdue University
Curated by ChEMBL
Purdue University
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization assessed as protein assembly after 20 mins by turbidimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of bovine tubulin assembly after 15 mins by turbidimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Evaluated for the inhibitory concentration against porcine brain tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of porcine brain tubulin polymerization after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin polymerization preincubated for 15 mins followed by GTP addition measured after 20 mins by spectrophotometric meth...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Compound was evaluated for in vitro inhibitory activity against polymerization of tubulin into microtubules isolated from bovine brain at 1 mg/mL tub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of tubulin polymerization upon incubation for 20 min at 30 degree CMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of MDR1 (unknown origin) transfected in human SKOV3 cells assessed as growth inhibition after 48 hrs by SRB assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Concentration required to inhibit the extent of glutamate-dependent tubulin polymerization by 50% at 37 degrees C(1.0 mM MgCl2)More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Ability to inhibit Tubulin polymerization in Bovine brainMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro tubulin polymerization-inhibitory activity.More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of tubulin polymerization with preincubation for 15 minutes at 37 degree Centigrade prior to addition of the GTP required for polymerizati...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Evaluated for the inhibition of tubulin polymerization without pre-incubationMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
Affinity DataIC50: 660nMAssay Description:Concentration inhibiting tubulin polymerization (ITP)More data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair