BDBM50002653 ((2R,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl)-(2-methoxy-benzyl)-amine::(2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl)-(2-methoxy-benzyl)-amine::CHEMBL419500::[(2R,3R)-2-(2,2-Diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-(2-methoxy-benzyl)-amine

SMILES COc1ccccc1CN[C@H]1C2CCN(CC2)[C@@H]1C(c1ccccc1)c1ccccc1

InChI Key InChIKey=FLNYLINBEZROPL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50002653   

TargetSubstance-P receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50002653(CHEMBL419500 | ((2R,3S)-2-Benzhydryl-1-aza-bicyclo...)
Affinity DataIC50: 10nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50002653(CHEMBL419500 | ((2R,3S)-2-Benzhydryl-1-aza-bicyclo...)
Affinity DataIC50: 41nMAssay Description:Binding affinity towards Tachykinin receptor 1 in human IM-9 cells using [3H]-substance P as ligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50002653(CHEMBL419500 | ((2R,3S)-2-Benzhydryl-1-aza-bicyclo...)
Affinity DataIC50: 800nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSubstance-P receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50002653(CHEMBL419500 | ((2R,3S)-2-Benzhydryl-1-aza-bicyclo...)
Affinity DataIC50: 0.330nMAssay Description:Inhibitory concentration against tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50002653(CHEMBL419500 | ((2R,3S)-2-Benzhydryl-1-aza-bicyclo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory concentration against tachykinin receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50002653(CHEMBL419500 | ((2R,3S)-2-Benzhydryl-1-aza-bicyclo...)
Affinity DataIC50: 8.10E+4nMAssay Description:Antagonist activity at His6-tagged NK1 receptor (unknown origin) expressed in CHO cells assessed as inhibition of substance-P-induced IP1 accumulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed