BDBM50002587 CHEMBL2113184

SMILES COc1cc2c(NC3=CC(=O)C(OCCN(C)c4ccccc4)=CC3=O)ncnc2cc1OCC1CCN(C)CC1

InChI Key InChIKey=MUKKZDFFRCURFS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50002587   

TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50002587(CHEMBL2113184)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50002587(CHEMBL2113184)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 5% mouse plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50002587(CHEMBL2113184)
Affinity DataIC50: 329nMAssay Description:Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50002587(CHEMBL2113184)
Affinity DataIC50: 15nMAssay Description:Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP and in presence of 100 uM glutathioneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed