BDBM50001898 1-Phenyl-piperazine::CHEMBL9434::PHENYLPIPERAZINE

SMILES c1ccc(cc1)N2CCNCC2

InChI Key InChIKey=YZTJYBJCZXZGCT-UHFFFAOYSA-N

Data  19 KI  2 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50001898   

TargetBeta-1 adrenergic receptor(Human)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataIC50: 1.90E+4nMAssay Description:Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Dog)
Berlex Laboratories

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung ti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  63nMAssay Description:Binding affinity in radioreceptor binding assay by using [3H]5-HT radioligand against 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  135nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  149nMAssay Description:Binding affinity in radioreceptor binding assay by using [3H]5-HT radioligand against 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  149nMAssay Description:Inhibition of [3H]5-HT radioligand binding against 5-hydroxytryptamine 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  380nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  380nMAssay Description:Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  380nMAssay Description:Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  380nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Rat)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  430nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2011
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  500nMAssay Description:Displacement of [3H]2-(di-N-propylamino)-8-hydroxytetralin from central 5-hydroxytryptamine 1A receptor recognition sites in rat frontal cortex homog...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  500nMAssay Description:Binding affinity was evaluated by determining in vitro displacement of [3H]8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition sit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  668nMAssay Description:Binding affinity at rat 5-hydroxytryptamine 2 receptor by [3H]ketanserin displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  794nMAssay Description:Binding affinity against rat Alpha-1 adrenergic receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity at rat Dopamine receptor D1 by [3H]SCH-23390 displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against rat Dopamine receptor D2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  2.10E+3nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  3.00E+3nMAssay Description:Compound was tested for the inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Mcneil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  6.80E+3nMAssay Description:In vitro displacement of [3H]spiperone from Dopamine receptor D2 binding site in rat striatum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50001898(CHEMBL9434 | 1-Phenyl-piperazine | PHENYLPIPERAZIN...)
Affinity DataKi:  1.14E+4nMAssay Description:The compound was tested for its binding affinity towards sigma receptor in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed