BDBM50001447 CHEMBL217406::His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2::His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2(NeurokininA)
SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)C)C(N)=O
InChI Key InChIKey=HEAUFJZALFKPBA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50001447
Affinity DataIC50: 7.70nMAssay Description:Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin AMore data for this Ligand-Target Pair
Affinity DataEC50: 53nMAssay Description:Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibitory activity against human Tachykinin receptor 2More data for this Ligand-Target Pair
Affinity DataEC50: 64.8nMAssay Description:Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.550nMAssay Description:Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryMore data for this Ligand-Target Pair
Affinity DataEC50: 563nMAssay Description:In vitro agonistic activity against tachykinin receptor 3 of everted rat protal vein.More data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Compound was evaluated for its ability to displace [3H]NKB binding in hNK3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Binding affinity towards Tachykinin receptor 1 binding in guinea pig cerebral cortex membranes was determined using [3H]SP as the radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Binding affinity towards Tachykinin receptor 1 in rat cerebral cortex membranes was determined by using 125 [I]-BHSP as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Tested for inhibition of tachykinin 1 (NK1) receptor in rat brain synaptosomal membranes using [125I]BH-SP as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:In vitro agonistic activity against tachykinin receptor 1 of guinea pig ileum longitudinal smooth muscle.More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2More data for this Ligand-Target Pair
Affinity DataKi: 0.710nMAssay Description:The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Compound was evaluated for affinity towards human tachykinin NK-1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 3.70E+3nMAssay Description:Evaluated for the binding affinity against NK2 receptorMore data for this Ligand-Target Pair