BDBM496860 SARS-CoV-2 PLpro Inhibitor, 90::US20240166598, Compound XR8-77
SMILES C[C@@H](NC(=O)c1cc(NC2CNC2)ccc1C)c1cccc(c1)-c1ccc(CNC2CCNC2=O)s1
InChI Key InChIKey=NFWQGKLIEDRSFG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 496860
Affinity DataIC50: 640nMAssay Description:The PLpro primary assay, which measures protease activity with the short peptide substrate Z-RLRGG-AMC (Bachem), was performed in black flat-bottom 3...More data for this Ligand-Target Pair
Affinity DataKd: 1.37E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 ug/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
Affinity DataIC50: 640nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
Affinity DataIC50: 640nMAssay Description:The PLpro primary assay using PLpro as prepared above was conducted as described below and provided the data described in Table 7 in the column: Enzy...More data for this Ligand-Target Pair
Affinity DataKd: 1.78E+3nMAssay Description:The PLpro primary assay using PLpro as prepared above was conducted as described below and provided the data described in Table 7 in the column: Enzy...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona
US Patent
University of Arizona
US Patent
Affinity DataIC50: 640nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona
US Patent
University of Arizona
US Patent
Affinity DataKd: 1.78E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair