BDBM496554 SARS-CoV-2 PLpro Inhibitor, 8::US20240166598, Compound ZN-2-187

SMILES C[C@@H](NC(=O)c1cc(NC(=O)C2CCNCC2)ccc1C)c1cccc2ccccc12

InChI Key InChIKey=QIXFKLPOAIIFGF-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 496554   

TargetReplicase polyprotein 1ab(2019-nCoV)
University of Illinois At Chicago

LigandPNGBDBM496554(SARS-CoV-2 PLpro Inhibitor, 8 | US20240166598, Com...)
Affinity DataIC50: 800nMAssay Description:The PLpro primary assay, which measures protease activity with the short peptide substrate Z-RLRGG-AMC (Bachem), was performed in black flat-bottom 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Illinois At Chicago

LigandPNGBDBM496554(SARS-CoV-2 PLpro Inhibitor, 8 | US20240166598, Com...)
Affinity DataKd:  5.40E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 ug/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Illinois At Chicago

LigandPNGBDBM496554(SARS-CoV-2 PLpro Inhibitor, 8 | US20240166598, Com...)
Affinity DataIC50: 800nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona

US Patent
LigandPNGBDBM496554(SARS-CoV-2 PLpro Inhibitor, 8 | US20240166598, Com...)
Affinity DataIC50: 800nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1a [1564-1878](Severe acute respiratory syndrome coronavirus (SAR...)
University of Arizona

US Patent
LigandPNGBDBM496554(SARS-CoV-2 PLpro Inhibitor, 8 | US20240166598, Com...)
Affinity DataKd:  5.40E+3nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 pg/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2024
Entry Details
Go to US Patent