BDBM493644 US10988445, Example 406

SMILES CS(=O)(=O)c1ccc2C(N(Cc2c1)C=O)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=WSYNGRJEQCLVHJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 493644   

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493644(US10988445, Example 406)
Affinity DataIC50: 50.1nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493644(US10988445, Example 406)
Affinity DataIC50: 158nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493644(US10988445, Example 406)
Affinity DataIC50: 51nMAssay Description:Inverse agonist activity at human RORC2 assessed as inhibition of SRC1-derived coactivator peptide by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM493644(US10988445, Example 406)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM493644(US10988445, Example 406)
Affinity DataIC50: 9.90E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed