BDBM492893 N-((6-amino-2,4- dimethylpyridin-3- yl)methyl)-5-((3- chloroquinolin-6- yl)methyl)nicotinamide::US10981893, Example 22

SMILES Cc1cc(N)nc(C)c1CNC(=O)c1cncc(Cc2ccc3ncc(Cl)cc3c2)c1

InChI Key InChIKey=ZCNTWWKRHUKJJH-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 492893   

TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(US10981893, Example 22 | N-((6-amino-2,4- dimethyl...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(US10981893, Example 22 | N-((6-amino-2,4- dimethyl...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(US10981893, Example 22 | N-((6-amino-2,4- dimethyl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human plasma kallikrein usingPro-Phe-Arg-AMC as substrate incubated for 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed