BDBM492588 6-Amino-4-(4-hydroxy-3-(trifluoromethyl)phenyl)-3-(thiophen-2-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile::US10980781, Compound 6q::US10980781, Compound 6v::US10980781, Entry 15::US11617738, Compound 6v

SMILES NC1=C(C#N)C(c2c(O1)n[nH]c2-c1cccs1)c1ccc(O)c(c1)C(F)(F)F

InChI Key InChIKey=TWMYUCMYQOVQMX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 492588   

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM492588(US10980781, Compound 6q | US10980781, Entry 15 | 6...)
Affinity DataIC50: 1.10E+4nMAssay Description:The lyophilized compounds were re-suspended in 100% DMSO to a stock concentration of 10 mM and stored at −20° C. Where Ratesample is the initia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM492588(US10980781, Compound 6q | US10980781, Entry 15 | 6...)
Affinity DataIC50: 750nMAssay Description:The lyophilized compounds were re-suspended in 100% DMSO to a stock concentration of 10 mM and stored at −20° C. Where Ratesample is the initia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM492588(US10980781, Compound 6q | US10980781, Entry 15 | 6...)
Affinity DataIC50: 1.10E+4nMAssay Description:The percent inhibition of USP7 at 100 μM of each compound was determined prior to the determination of IC50 values. The final concentration of s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
Go to US Patent

TargetUbiquitin carboxyl-terminal hydrolase 7(Human)
Purdue Research Foundation

US Patent
LigandPNGBDBM492588(US10980781, Compound 6q | US10980781, Entry 15 | 6...)
Affinity DataIC50: 750nMAssay Description:The percent inhibition of USP7 at 100 μM of each compound was determined prior to the determination of IC50 values. The final concentration of s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2023
Entry Details
Go to US Patent