BDBM489284 2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(2S)-2-(hydroxymethyl)-5-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-4-methyl-1,3-thiazol-5-yl]-N-methyl-3-oxo-2,3-dihydro-1H-isoindole-4-sulfonamide::US10961236, Example 57

SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2[C@H](CO)CCC2=O)nc1C

InChI Key InChIKey=IKNJUYUINPOVDE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489284   

LigandPNGBDBM489284(US10961236, Example 57 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 0.700nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM489284(US10961236, Example 57 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 1.20nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM489284(US10961236, Example 57 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 11nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM489284(US10961236, Example 57 | 2-[(1S)-1-Cyclopropylethy...)
Affinity DataIC50: 85nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In DepthDetails
US Patent