BDBM489230 2-[(1S)-1-Cyclopropylethyl]-5-(4-methyl-2-{[6-(2-oxopiperidin-1-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-7-(methylsulfonyl)-2,3-dihydro-1H-isoindol-1-one::US10961236, Example 4

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1sc(Nc2cccc(n2)N2CCCCC2=O)nc1C

InChI Key InChIKey=SFTPPASPRIXXIN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 489230   

LigandPNGBDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 16nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 250nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kdelta in anti-IgM-stimulated human JeKo-1 cells assessed as inhibition of AKT phosphorylation at Ser473 residue incubated for 60 mi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM489230(US10961236, Example 4 | 2-[(1S)-1-Cyclopropylethyl...)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human PI3Kalpha assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed