BDBM48901 BDBM160086::US10047092, 27::US10053463, 27::US9040534, 72

SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F

InChI Key InChIKey=ITPQWLNFTIKNLD-UHFFFAOYSA-N

Data  7 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 48901   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 0.900nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 36.1nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at rat P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 36.1nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 36.1nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataIC50: 5.60nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataKi:  0.400nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataKi:  0.400nMAssay Description:Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataKi:  0.400nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataKi:  2nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataKi:  2nMAssay Description:Radioligand binding: human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataKi:  2nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM48901(US10047092, 27 | BDBM160086 | US9040534, 72 | US10...)
Affinity DataKi:  2.5nMpH: 7.4Assay Description:Ca2+ Flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
Go to US Patent