BDBM488247 2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyrrolidin-1-yl) phenyl)-4-(3-fluoro-4- sulfamoylbenzyl)-1H- pyrazol-1-yl)thiazole-4- carboxylic acid::US10954228, Compound 202::US11752138, Compound 202

SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2ccc(F)c(c2)N2CCCC2=O)-c2nc(cs2)C(O)=O)cc1F

InChI Key InChIKey=MWLSQYWAMNFBDY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 488247   

TargetL-lactate dehydrogenase A chain(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM488247(2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyr...)
Affinity DataIC50: 100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
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TargetL-lactate dehydrogenase A chain(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM488247(2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyr...)
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
The Trustees of The University of Pennsylvania

US Patent
LigandPNGBDBM488247(2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyr...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of LDHA in human MIA PaCa2 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetL-lactate dehydrogenase B chain(Human)
Vanderbilt University

US Patent
LigandPNGBDBM488247(2-(5-(cyclopropylmethyl)- 3-(4-fluoro-3-(2- oxopyr...)
Affinity DataIC50: 100nMAssay Description:This example describes a human LDHB biochemical assay employed in the characterization of a compound of Formula I in an embodiment of the dislcosure....More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
Go to US Patent