BDBM488100 N-(4-(1-Ethyl-3- (pyridin-3-yl)-1H- pyrazol-4- yl)pyrimidin-2-yl)- 2,3,4,5-tetrahydro- 1H-benzo [d] azepin- 7-amine::US10954216, Example 171

SMILES CCn1cc(c(n1)-c1cccnc1)-c1ccnc(Nc2ccc3CCNCCc3c2)n1

InChI Key InChIKey=UVNFZIZQFBEMTB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488100   

TargetActivin receptor type-1 [R206H](Human)
Riken

US Patent
LigandPNGBDBM488100(N-(4-(1-Ethyl-3- (pyridin-3-yl)-1H- pyrazol-4- yl)...)
Affinity DataIC50: 11nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Riken

US Patent
LigandPNGBDBM488100(N-(4-(1-Ethyl-3- (pyridin-3-yl)-1H- pyrazol-4- yl)...)
Affinity DataIC50: 17nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent