BDBM488093 3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrimidin-4-yl)-3-(pyridin- 3-yl)-1H-pyrazol-1- yl)methyl)benzonitrile::US10954216, Example 156

SMILES N#Cc1cccc(Cn2cc(c(n2)-c2cccnc2)-c2ccnc(Nc3ccc(cc3)N3CCNCC3)n2)c1

InChI Key InChIKey=KLEUCXDEXNSEGN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488093   

TargetActivin receptor type-1 [R206H](Human)
Riken

US Patent
LigandPNGBDBM488093(3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrim...)
Affinity DataIC50: 5.40nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetActivin receptor type-1(Human)
Riken

US Patent
LigandPNGBDBM488093(3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrim...)
Affinity DataIC50: 6.10nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent