BDBM486539 US10947251, Example 16

SMILES COc1cc(c(F)cc1N1[C@H]2CCN(C[C@@H]2OCC1=O)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)F

InChI Key InChIKey=CLRANRQVIWLROH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 486539   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM486539(US10947251, Example 16)
Affinity DataIC50: 1.39E+3nMAssay Description:Heterologously Express hNav1.7 and the β1 SubunitPreparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM486539(US10947251, Example 16)
Affinity DataIC50: 49.5nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
Go to US Patent