BDBM484468 US10934285, Example 54::US12053470, Compound 54

SMILES CN1C(Cc2ccccc2)C(O)=C(C(=O)Nc2cccc(Sc3ncc(nc3N)N3CCC(C)(N)CC3)c2Cl)C1=O

InChI Key InChIKey=JJTYMCPMKUFMGA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484468   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484468(US10934285, Example 54 | US12053470, Compound 54)
Affinity DataIC50: 7.30nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
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LigandPNGBDBM484468(US10934285, Example 54 | US12053470, Compound 54)
Affinity DataIC50: 7.30nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent