BDBM484467 US10934285, Example 53::US12053470, Compound 46

SMILES CC1(N)CCN(CC1)c1cnc(Sc2cccc(NC(=O)C3=C(O)CN(C3=O)c3ccccc3)c2Cl)c(N)n1

InChI Key InChIKey=JBTYRLRPDPSWAY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484467   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484467(US10934285, Example 53 | US12053470, Compound 46)
Affinity DataIC50: 4.40nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
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LigandPNGBDBM484467(US10934285, Example 53 | US12053470, Compound 46)
Affinity DataIC50: 4nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent