BDBM484430 US10934285, Example 14::US12053470, Compound 51

SMILES Nc1nc(cnc1Sc1cccc(NC(=O)c2c(O)nc3CCCCn3c2=O)c1Cl)N1CCC(N)(CF)CC1

InChI Key InChIKey=QQGWBWWGXPNCEH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484430   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484430(US10934285, Example 14 | US12053470, Compound 51)
Affinity DataIC50: 5.90nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM484430(US10934285, Example 14 | US12053470, Compound 51)
Affinity DataIC50: 6nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails
US Patent