BDBM484429 US10934285, Example 13::US12053470, Compound 52

SMILES Nc1nc(cnc1Sc1cccc(NC(=O)c2c(O)nc3ccccn3c2=O)c1Cl)N1CCC(N)(CF)CC1

InChI Key InChIKey=ZVBSVBHUEYAOGL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484429   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484429(US10934285, Example 13 | US12053470, Compound 52)
Affinity DataIC50: 4.60nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
NOVARTIS AG; THE GENERAL HOSPITAL CORPORATION

US Patent
LigandPNGBDBM484429(US10934285, Example 13 | US12053470, Compound 52)
Affinity DataIC50: 5nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In DepthDetails
US Patent