BDBM484418 US10934285, Example 2::US12053470, Compound 50

SMILES CC1(CN)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4ccccn4c3=O)c2Cl)c(N)n1

InChI Key InChIKey=SXLOCFFGRYJKJH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484418   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484418(US10934285, Example 2 | US12053470, Compound 50)
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
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LigandPNGBDBM484418(US10934285, Example 2 | US12053470, Compound 50)
Affinity DataIC50: 7nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent