BDBM483491 US10925881, Name (S)-JQ35

SMILES CN1CCN(CCCNC(=O)C[C@@H]2N=C(c3c(C)c(C)sc3-n3c(C)nnc23)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=PKQXLRYFPSZKDU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483491   

TargetBromodomain-containing protein 4 [44-167](Human)
Tensha Therapeutics

US Patent
LigandPNGBDBM483491(US10925881, Name (S)-JQ35)
Affinity DataIC50: 24.3nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Tensha Therapeutics

US Patent
LigandPNGBDBM483491(US10925881, Name (S)-JQ35)
Affinity DataIC50: 6.13nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent