BDBM482160 BDBM50396041::HG-10-102-01

SMILES CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl

InChI Key InChIKey=YEVOZZZLKJKCCD-UHFFFAOYSA-N

Data  3 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 482160   

LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 600nMAssay Description:Inhibition of MNK2 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of MLK1 by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 20.3nMAssay Description:Inhibition of LRRK2 expressed in HEK293 cells using nictide as substrate and [gamma32P]ATP after 15 mins by Cerenkov counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 29nMAssay Description:Inhibition of autophosphorylation of LRRK2 in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 20nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 20.3nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,G2019S](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 3.20nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [1326-2527,A2016T](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 154nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataIC50: 95.9nMAssay Description:Active GST-LRRK2 (1326-2527), GST-LRRK2[G2019S] (1326-2527), GST-LRRK2[A2016T] (1326-2527) and GST-LRRK2[A2016T+G2019S] (1326-2527) enzyme was purifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2021
Entry Details
Go to US Patent

LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataKi:  3nMAssay Description:Inhibition of LRRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataKi:  3nMAssay Description:Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM482160(HG-10-102-01 | BDBM50396041)
Affinity DataKi: >3.20E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed