BDBM480928 8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)amino]pyrimidin-5-yl}methanone::US10906888, Example 142::US20240083873, Compound A::US20240124479, Compound A
SMILES O=C(N1CCC2(C1)CCOCC2)c1cnc(NCc2cnccn2)nc1
InChI Key InChIKey=VGRLXWFIXGZRMS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 480928
Affinity DataIC50: 7.66nMAssay Description:The test inhibitors were solubilized in DMSO to a stock concentration of 30 mM. On the day of the assay, dose response plates were prepared by diluti...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of mouse vanin-1More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human plasma vanin-1 using pantetheine-7-amino-4-trifluoromethykournarin as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of N-terminal FLAG/His6-tagged human biotinidase expressed in COS cells using biotinyl-7-amino-4-trifluoromethylcoumarin as substrate prei...More data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of mouse plasma vanin-1More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Wistar han rat serum vanin-1More data for this Ligand-Target Pair
Affinity DataIC50: 11.2nMAssay Description:A certain mass of the compound was weighed precisely, and prepared with DMSO and reaction buffer (50 mM Tris base, 50 mM KCl, 1.6 mM cysteamine, 0.00...More data for this Ligand-Target Pair
Affinity DataIC50: 11.2nMAssay Description:A certain mass of the compound was weighed precisely, and prepared with DMSO and reaction buffer (50 mM Tris base, 50 mM KCl, 1.6 mM cysteamine, 0.00...More data for this Ligand-Target Pair