BDBM479351 (3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5]decan- 8-yl)-6-(((6aS,8S)-8-(((methoxymethoxy)meth- oxy)methyl)-6a,7,8,9-tetrahydro-6H-pyrido[3,2- b]pyrrolo[1,2-d][1,4]oxazin-4-yl)thio)pyrazin- 2-yl)methanol::US10894797, Compound 40::US11034705, Compound 40::US11518772, Compound 40

SMILES COCOCOC[C@H]1C[C@H]2COc3c(Sc4cnc(N5CCC6(CO[C@@H](C)[C@H]6N)CC5)c(CO)n4)ccnc3N2C1

InChI Key InChIKey=ARCKFDMKZIEWRQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 479351   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479351((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50: 5.90nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetSH2B adapter protein 2(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479351((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50: 5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479351((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50: 5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
Go to US Patent