BDBM479319 (6aS,8R)-4-((5-((3S,4S)-4-amino-3-methyl-2oxa-8- azaspiro[4.5]decan-8-yl)-6-(hydroxymethyl)pyrazin- 2-yl)thio)-6a,7,8,9-tetrahydro-6H-pyrido[3,2- b]pyrrolo[1,2-d][1,4]oxazin-8-ol::US10894797, Compound 8::US11459340, Compound 19::US11518772, Compound 8

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@H](O)CC5COc34)nc2CO)[C@@H]1N

InChI Key InChIKey=SBXJSYHXBGIJJB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 479319   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479319((6aS,8R)-4-((5-((3S,4S)-4-amino-3-methyl-2oxa-8- a...)
Affinity DataIC50: 8nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479319((6aS,8R)-4-((5-((3S,4S)-4-amino-3-methyl-2oxa-8- a...)
Affinity DataIC50: 8nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479319((6aS,8R)-4-((5-((3S,4S)-4-amino-3-methyl-2oxa-8- a...)
Affinity DataIC50: 8nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent