BDBM479122 N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrrolidine-1-carbonyl)-2- (((R)-1-methylpyrrolidin-3- yl)oxy)phenyl)acrylamide::US10894788, Example 163::US11390618, Example 163

SMILES CN1CC[C@H](C1)Oc1cc(ccc1NC(=O)C=C)C(=O)N1CC[C@H](C1)Nc1ncc(Br)cn1

InChI Key InChIKey=QKDOSLCTSQDNIY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 479122   

TargetCyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM479122(N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of compounds was determined using one protein kinase in a customized, thiol free assay. IC50 values were measured by testing 10 conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
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TargetCyclin-K/Cyclin-dependent kinase 12(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM479122(N-(4-((R)-3-((5-bromopyrimidin-2- yl)amino)pyrroli...)
Affinity DataIC50: 100nMAssay Description:The IC50 profile of test compounds was determined using three protein kinases. IC50 values were measured by testing 10 concentrations (1×10−04M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2022
Entry Details
Go to US Patent