BDBM478949 2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-bipyridin]-5-yl)-N-(5-cyclopropyl- 1H-pyrazol-3-yl)propanamide::US10894786, Comp. No 51

SMILES CC#CC(=O)N1CCC(=CC1)c1ccc(cn1)C(C)C(=O)Nc1cc([nH]n1)C1CC1

InChI Key InChIKey=AWAHFDYWQKGERT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 478949   

TargetCyclin-dependent kinase 12(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478949(2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-b...)
Affinity DataIC50: 203nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 13(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478949(2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-b...)
Affinity DataIC50: 25nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478949(2-(1'-(but-2-ynoyl)-1',2',3',6'-tetrahydro-[2,4'-b...)
Affinity DataIC50: 1.69E+3nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent