BDBM478944 2-(6-(1-acryloyl-2,5-dihydro-1H-pyrrol-3-yl)pyridin-3-yl)-N-(5-cyclopropyl-1H- pyrazol-3-yl)propanamide::US10894786, Comp. No 46::US10894786, Comp. No 47

SMILES CC(C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(nc1)C1=CCN(C1)C(=O)C=C

InChI Key InChIKey=KPCQQZMELPQBCN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 478944   

TargetCyclin-dependent kinase 12(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478944(US10894786, Comp. No 46 | US10894786, Comp. No 47 ...)
Affinity DataIC50: 32nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 13(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478944(US10894786, Comp. No 46 | US10894786, Comp. No 47 ...)
Affinity DataIC50: 6.90nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 12(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478944(US10894786, Comp. No 46 | US10894786, Comp. No 47 ...)
Affinity DataIC50: 676nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 13(Human)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478944(US10894786, Comp. No 46 | US10894786, Comp. No 47 ...)
Affinity DataIC50: 6nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent