BDBM477985 3-cyano-N-(2-hydroxyethyl)-2-oxo-4-(6-aza-spiro[2.5]oct-6-yl)-1,2-dihydro-1,7-naphthyridin-6-carboxamide ::US10889591, Compound 97::US11434248, Compound 97

SMILES OCCNC(=O)c1cc2c(N3CCC4(CC4)CC3)c(C#N)c(=O)[nH]c2cn1

InChI Key InChIKey=AWNHWSFXYGDQRW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477985   

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing Transthera Biosciences

US Patent
LigandPNGBDBM477985(US10889591, Compound 97 | 3-cyano-N-(2-hydroxyethy...)
Affinity DataIC50: 27nMAssay Description:1. Experimental materials and instrumentsPDE9A2 Enzyme (BPS, Cat. No. 60090)384-well plate (Perkin Elmer, Cat. No. 6007279)2. Experimental procedureP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing Transthera Biosciences

US Patent
LigandPNGBDBM477985(US10889591, Compound 97 | 3-cyano-N-(2-hydroxyethy...)
Affinity DataIC50: 27nMAssay Description:Test substance: Compounds of the invention, prepared by the corresponding examples of the invention1. Experimental materials and instrumentsPDE9A2 En...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
Go to US Patent