BDBM477951 6-isopropyl-2-oxo-4-(7-azaspiro[3.5]nonane-7-yl)-1,2-dihydro-1,7-naphthyridin-3-carbonitrile ::US10889591, Compound 47::US11434248, Compound 47

SMILES CN(C)c1cc2c(N3CCC4(CCC4)CC3)c(C#N)c(=O)[nH]c2cn1

InChI Key InChIKey=YETRDDMTTQAQNM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 477951   

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing Transthera Biosciences

US Patent
LigandPNGBDBM477951(US10889591, Compound 47 | 6-isopropyl-2-oxo-4-(7-a...)
Affinity DataIC50: 12nMAssay Description:1. Experimental materials and instrumentsPDE9A2 Enzyme (BPS, Cat. No. 60090)384-well plate (Perkin Elmer, Cat. No. 6007279)2. Experimental procedureP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Nanjing Transthera Biosciences

US Patent
LigandPNGBDBM477951(US10889591, Compound 47 | 6-isopropyl-2-oxo-4-(7-a...)
Affinity DataIC50: 12nMAssay Description:Test substance: Compounds of the invention, prepared by the corresponding examples of the invention1. Experimental materials and instrumentsPDE9A2 En...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2022
Entry Details
Go to US Patent