BDBM477892 (4S,6R)-2-amino-4-(2-fluoro-5-((Z)-2-fluoro-2-(5-(2-propyn-1-yloxy)-2-pyrazinyl)ethenyl)phenyl)-N,4,6-trimethyl-5,6-dihydro-4H-1,3-thiazine-6-carboxamide; and::US10889579, Example 112

SMILES CNC(=O)[C@@]1(C)C[C@](C)(N=C(N)S1)c1cc(\C=C(/F)c2cnc(OCC#C)cn2)ccc1F

InChI Key InChIKey=DUXJJGZUZXKWAW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 477892   

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477892(US10889579, Example 112 | (4S,6R)-2-amino-4-(2-flu...)
Affinity DataIC50: 37nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
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TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477892(US10889579, Example 112 | (4S,6R)-2-amino-4-(2-flu...)
Affinity DataIC50: 1.31E+3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM477892(US10889579, Example 112 | (4S,6R)-2-amino-4-(2-flu...)
Affinity DataIC50: 7.99E+4nMAssay Description:Recombinant CatD was expressed in CHO cells. The assay buffer for CatD was 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The CatD enzyme (9 nM) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent