BDBM477424 4-chloro-N-((1S,2R)-2-(6-fluoro-2,3-dimethylphenyl)-1-(5-oxo-4,5::US10889555, Example 204::US11634395, Example 208B

SMILES COc1c(ccc(Cl)c1C(C)O)S(=O)(=O)N[C@@H]([C@H](C)c1c(F)ccc(C)c1C)c1n[nH]c(=O)o1

InChI Key InChIKey=VAVAMZWIHKTIFJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 477424   

TargetMuscarinic acetylcholine receptor M1/M2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM477424(US10889555, Example 204 | 4-chloro-N-((1S,2R)-2-(6...)
Affinity DataIC50: 150nMAssay Description:First, test compounds were serially diluted with DMSO. Next, human M1 protein and human M2 protein were added to an aqueous albumin solution derived ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandPNGBDBM477424(US10889555, Example 204 | 4-chloro-N-((1S,2R)-2-(6...)
Affinity DataIC50: 150nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
Go to US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandPNGBDBM477424(US10889555, Example 204 | 4-chloro-N-((1S,2R)-2-(6...)
Affinity DataIC50: 100nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
Go to US Patent

TargetRibonucleoside-diphosphate reductase large subunit/subunit M2(Human)
Taiho Pharmaceutial

US Patent
LigandPNGBDBM477424(US10889555, Example 204 | 4-chloro-N-((1S,2R)-2-(6...)
Affinity DataIC50: 60nMAssay Description:The inhibitory activity against the ribonucleotide reduction reaction (hereinafter referred to as RNR reaction) of the test compound was determined b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
Go to US Patent