BDBM476992 Inhibitor 12 of SARS-CoV-2 Mpro::US20240092759, Compound 49

SMILES Clc1sccc1COc1cc(Cl)cc(c1)-c1cc(cn(-c2cccnc2)c1=O)-c1c[nH]c(=O)[nH]c1=O

InChI Key InChIKey=GNSONAJPJOULHV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 476992   

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476992(Inhibitor 12 of SARS-CoV-2 Mpro | US20240092759, C...)
Affinity DataIC50: 27nMAssay Description:Purified protein is diluted in reaction buffer to 100 nM in an opaque 96-well plate. The protein is incubated with or without compound in DMSO at dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM476992(Inhibitor 12 of SARS-CoV-2 Mpro | US20240092759, C...)
Affinity DataIC50: 26.5nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent