BDBM476977 Inhibitor 2 of SARS-CoV-2 Mpro::US20240092759, Compound 13

SMILES CCCOc1cc(cc(c1)Cl)C2=CC(=CN(C2=O)c3cccnc3)c4ccccc4C#N

InChI Key InChIKey=KFGXONJZGIXSGH-UHFFFAOYSA-N

Data  3 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 476977   

TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476977(Inhibitor 2 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50: 140nMAssay Description:Purified protein is diluted in reaction buffer to 100 nM in an opaque 96-well plate. The protein is incubated with or without compound in DMSO at dif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476977(Inhibitor 2 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.51E+3nMAssay Description:These include a rapid screening replicon assay using baby hamster kidney (BHK) cells with noninfectious SARS-CoV-2, in which the spike protein in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Yale University

LigandPNGBDBM476977(Inhibitor 2 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataEC50:  1.50E+3nMAssay Description:These assays are from various references.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM476977(Inhibitor 2 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50: 140nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1a(2019-nCoV)
Yale University

US Patent
LigandPNGBDBM476977(Inhibitor 2 of SARS-CoV-2 Mpro | US20240092759, Co...)
Affinity DataIC50: 140nMAssay Description:Inhibition of proteolytic activity was tested using recombinant SARS-Cov-2 Mpro, as described herein in the Experimental section. For the kinetic ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2024
Entry Details
Go to US Patent