BDBM476654 (2S,4R)-1-[(2S)-3-[4-(Aminomethyl)phenyl]-2-[[2-(3-chlorophenyl)-2,2-difluoroacetyl]amino]propanoyl]-4-[(4-methoxyphenyl)methylsulfonyl]-N-[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]pyrrolidine-2-carboxamide::US10870623, Example 21

SMILES COc1ccc(CS(=O)(=O)[C@@H]2C[C@H](N(C2)C(=O)[C@H](Cc2ccc(CN)cc2)NC(=O)C(F)(F)c2cccc(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)cc1

InChI Key InChIKey=BSEDJUDGYSMRQL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 476654   

TargetSerine protease HTRA1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM476654((2S,4R)-1-[(2S)-3-[4-(Aminomethyl)phenyl]-2-[[2-(3...)
Affinity DataIC50: 1.99nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...More data for this Ligand-Target Pair
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Date in BDB:
7/25/2021
Entry Details
Go to US Patent