BDBM476626 N-(4-(2-propylhydrazine-1- carbonyl)benzyl)cinnamamide::US10870618, Compound 3b::US20240327418, Comparative example 1 LP411/3b
SMILES CCCNNC(=O)c1ccc(CNC(=O)\C=C\c2ccccc2)cc1
InChI Key InChIKey=MHZUZIALEUTHIU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 37 hits for monomerid = 476626
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate incubated for 30 mins by fluorescen...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 min...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 1 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 2 hrs ...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate incubated for 30 mins by fluoresce...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 30 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 1 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated with enzyme for 2 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 95.5nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 7.80nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as ...More data for this Ligand-Target Pair
Affinity DataIC50: 11.8nMAssay Description:a) Formulation of 100% solution: 50 μL of HDAC buffer was mixed with 10 μL of enzyme solution, 40 μL of substrate was added after 5 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 95.5nMAssay Description:a) Formulation of 100% solution: 50 μL of HDAC buffer was mixed with 10 μL of enzyme solution, 40 μL of substrate was added after 5 mi...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Human)
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
Affinity DataIC50: 0.950nMAssay Description:a) Formulation of 100% solution: 50 μL of HDAC buffer was mixed with 10 μL of enzyme solution, 40 μL of substrate was added after 5 mi...More data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Human)
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
Affinity DataIC50: 2.00E+4nMAssay Description:a) Formulation of 100% solution: 50 μL of HDAC buffer was mixed with 10 μL of enzyme solution, 40 μL of substrate was added after 5 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-Lys(acetyl)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11.8nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Human)
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
Affinity DataIC50: 0.950nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Human)
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
Affinity DataIC50: 0.950nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Human)
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
Affinity DataIC50: 124nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC1 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminomethyl couma...More data for this Ligand-Target Pair
Affinity DataIC50: 95nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC2 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminomethyl couma...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(acetyl)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-Lys(acetyl)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Human)
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
OCEAN UNIVERSITY OF CHINA; QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD; MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD
US Patent
Affinity DataIC50: 0.950nMAssay Description:Inhibition of human recombinant HDAC3 using Boc-Lys(acetyl)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC11 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC4 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC5 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC7 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC8 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC9 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human recombinant HDAC10 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
University of Copenhagen
Curated by ChEMBL
University of Copenhagen
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC3 (unknown origin)/N-terminal GST-tagged NCoR2 (unknown origin) assessed as equilibrium inhibitio...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of full length C-terminal His-tagged HDAC1 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrat...More data for this Ligand-Target Pair
Affinity DataKi: 103nMAssay Description:Inhibition of full length C-terminal FLAG-tagged HDAC2 (unknown origin) assessed as inhibition constant (Ki) using (Ac-Leu-Gly-Lys(Ac)-AMC as substra...More data for this Ligand-Target Pair