BDBM476622 N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)benzamide::US10870618, Compound 2l

SMILES CCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1

InChI Key InChIKey=XFDKMPCSDVCXCQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 476622   

TargetHistone deacetylase 3(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476622(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)benzamid...)
Affinity DataIC50: 187nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476622(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)benzamid...)
Affinity DataIC50: 187nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476622(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)benzamid...)
Affinity DataIC50: 427nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM476622(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)benzamid...)
Affinity DataIC50: 399nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Ocean University of China

Curated by ChEMBL
LigandPNGBDBM476622(N-(4-(2-ethylhydrazine-1- carbonyl)benzyl)benzamid...)
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed