BDBM476613 N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzamide::US10870618, Compound 2e

SMILES CCCCCNNC(=O)c1ccc(CNC(=O)c2ccccc2)cc1

InChI Key InChIKey=HAPPIMWTPPPDNS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 476613   

TargetHistone deacetylase 1(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476613(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Affinity DataIC50: 20.2nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476613(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Affinity DataIC50: 43.6nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476613(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Affinity DataIC50: 18.7nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476613(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Affinity DataIC50: 19nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Musc Foundation For Research Development

US Patent
LigandPNGBDBM476613(N-(4-(2-pentylhydrazine-1- carbonyl)benzyl)benzami...)
Affinity DataIC50: 264nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed